Why Does Inflammation Result in Resorptive Bone Loss? What the Study of Burns Teaches Us

Burn injury serves as an example of a condition with robust systemic inflammatory response. The elevation circulating interleukins (IL)-1? and -6 in children adolescents severe burn upregulates the parathyroid calcium-sensing receptor (CaSR), resulting hypocalcemic hypoparathyroidism accompanied by urinary calcium wasting. This effect protects body from hypercalcemia that results bone resorption, liberating into circulation. Extracellular can exacerbate prolong response stimulating mononuclear cell chemokine production well NLRP3 inflammasome innate immune system, increased IL-1 monocytes macrophages. Interestingly, CaSR upregulation to cytokines disappears age, potentially trapping resorption circulation, allowing it contribute inflammation possibly deposition small arteries, such coronaries, conditions chronic inflammation, spinal cord injury, osteoarthritis, rheumatoid arthritis have incidence cardiovascular disease coronary artery significantly higher than unaffected age-matched population.